Source: Alice's animations
Hypothetical change in quaternary structure of the hexameric MenB enzyme. Protein molecules are constantly in motion, big or small. 面-B蛋白六胞胎有點像旋轉木馬, 每一團"雲狀物"代表一個面-B蛋白單胞胎，這些雲朵描繪出蛋白分子的表面。蛋白質分子經常改變表面的形狀。
Reference:
Vitamin K research by Institute for Chemical Biology & Drug Discovery, New York 紐約維他命K相關研究
Vitamin K research by Rudolf Virchow Center for Experimental Biomedicine, Würzburg 烏茲堡維他命K相關研究
Rudolf-Virchow Forschungszentrum für Experimentelle Biomedizin
Source: Biochemistry 2011, 50 (44), 9532–9544
The red loop has a difficult time finding a unique secondary structure until the black molecule comes into play. 研究人員利用圖中黑色分子來克服上述實驗的困難, 得以觀察紅色部分的蛋白質結構。
Clip 2: The making of vitamin K 打造維他命K
Jeremy, a young scientist and a high school teacher on Long Island, has never forgot the years in the research lab where he discovered how vitamin K was made from microorganisms through their internal biochemical machinery.傑若米是位任教於紐約長島的年輕中學教師。他難以忘懷執教之前在研究單位裡的時光，以及曾經參與的一項研究計劃: 自然界中微生物如何製造維他命K？
Clip 9: An incredible journey 尋夢之旅
Hongmei's husband encouraged her to pursue her scientific career abroad. She traveled from China to US on her own and participated in the vitamin K project. Several mimic molecules were designed to probe the interactions with the protein machinery. While performing the test in the lab, she attempted to protect her unborn baby from the potential hazard of the ultrasound generated from a device.
Clip 11: How long does it take before it works? 漫漫長路
For months, the positive response in the test tube has not been reproducible. Finally, Jackie identified the new molecule that induced the positive result with consistency. The next stage of the project, though, turned out to be even more challenging.
"How could this be possible?", cried Jackie.
Clip 26: There is such a thing as miracle 見證奇蹟
"My goodness! What is this?"
As the data were calculated and output from the computer screen, Wicky could not believe her eyes. It had been too long for her to keep the faith that she could ever get there. For the first time, the molecular picture of the protein is constructed without any ambiguity.
"What a beauty", sighed Wicky. Only if anyone else was around to witness it too.
Clip 40: Who is he? 何許人也
He is above the ceilings.
He is in the hallway.
He is outside my door.
He is behind my shoulder.
He is in the email.
He is on the phone.
He is in the news.
He is in every wire of my circuit.
He is in the trembling of aspen leaves.
He is among the whistling of the traveling bus.
He preaches in my dream.
他在樓層上;
在走廊裡;
在門外;
在我背後;
他捎信給我;
電話問候;
他上新聞;
他佔據了我的每條線路;
白楊樹葉的顫動中有他;
呼嘯而過的塵囂中有他;
在我的夢中他毫無倦態。
Clip 42: What does everyone want from me! 多頭馬車
Clip 11: How long does it take before it works? 漫漫長路
For months, the positive response in the test tube has not been reproducible. Finally, Jackie identified the new molecule that induced the positive result with consistency. The next stage of the project, though, turned out to be even more challenging.
"How could this be possible?", cried Jackie.
Clip 26: There is such a thing as miracle 見證奇蹟
"My goodness! What is this?"
As the data were calculated and output from the computer screen, Wicky could not believe her eyes. It had been too long for her to keep the faith that she could ever get there. For the first time, the molecular picture of the protein is constructed without any ambiguity.
"What a beauty", sighed Wicky. Only if anyone else was around to witness it too.
Clip 40: Who is he? 何許人也
He is above the ceilings.
He is in the hallway.
He is outside my door.
He is behind my shoulder.
He is in the email.
He is on the phone.
He is in the news.
He is in every wire of my circuit.
He is in the trembling of aspen leaves.
He is among the whistling of the traveling bus.
He preaches in my dream.
他在樓層上;
在走廊裡;
在門外;
在我背後;
他捎信給我;
電話問候;
他上新聞;
他佔據了我的每條線路;
白楊樹葉的顫動中有他;
呼嘯而過的塵囂中有他;
在我的夢中他毫無倦態。
With the approaching deadline, Patrick checked with the lab assistant the second time of the day, 'Can we have the results by Wednesday?'
'When are you coming home?' rang the phone with the frustrating voice of Heather.
'Heather you don't understand...' again Patrick trying to explain.
'Stop saying that I don't understand!' cried Heather.
眼看期限就要到了, Patrick不得不再次詢問實驗助理: 我們能在禮拜三之前交出來嗎？
電話裡傳來Heather掩不住失望憤怒的聲音: "你哪時候才能回家？"
"聽我說Heather, 你不懂..."
"不要總說我不懂！" Heather叫道。
This work by Microscopic Macromolecular Studio is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.